Royal Air Force Typhoon FGR4s have operated alongside French aircraft in a joint strike on an hidden munitions depot in Syrian territory used by the Daesh militant organization, per a report from the UK's MoD.
The location, located using surveillance, was assessed as housing weapons and explosive materials, the release indicated, and was positioned in hills just above Palmyra in the heart of Syria.
"The RAF jets employed Paveway IV guided bombs to hit a several access tunnels down to the site... initial indications suggest the objective was successfully hit," the MoD said.
There was no sign of any harm to civilians in the operation on Saturday evening and every plane involved returned safely, the ministry further stated.
The British jets were assisted by a Voyager tanker plane.
The Islamic State group - alternatively referred to as ISIS - enforced jihadist rule over parts of both Syria and Iraq until 2019.
"This operation underscores our UK leadership, and resolve to operate in unison with our allies, to eliminate any revival of IS and their harmful and extremist ideologies in the Middle East," the British Defence Secretary the minister stated.
RAF aircraft have carried out surveillance missions over Syria to "deter any attempted comeback" of IS subsequent to its routing at the Baghuz confrontation in the year 2019, the ministry said.
"I must thank every member of British forces involved in this operation for their skill and their valour," the Defence Secretary said. "They were among a great many UK service members stationed over the holidays. This operation, to remove militants who pose a risk to our way of life, shows how our armed forces are prepared to act, throughout the year, ensuring Britain's security within its borders and powerful internationally."
In December, the US military executed what it described as a "large-scale strike" against IS targets in the country, after an attack killed two US troops and a civilian linguist in Palmyra.
The United Nations reports Islamic State still maintains an estimated 5,000 to 7,000 combatants in both countries.